Biomet Spine & Bone Healing Technologies

Published Pre-clinical Data

Pre-clinical animal studies have shown the following:

Bone Morphogenetic Protein (BMP) Expression**
Prospective animal study of posterolateral lumbar spine fusion comparing autograft to autograft with rhBMP-2(1)

  • Not all BMPs expressed immediately post-op
  • Each BMP has a specific time and pattern of expression
  • BMP-2 mRNA is expressed later and to a lesser extent than BMP-6
  • BMP-6 appears to play a unique role as the earliest bone morphogenetic protein expressed during spine fusion healing

Direct Current (DC) Stimulation: BMP mRNA Upregulation**
Prospective animal study of posterolateral lumbar spine fusion comparing autograft to autograft with direct current (DC) stimulation

  • DC Stimulation up-regulates the gene expression of BMP-2, BMP-6 and BMP-7
  • DC stimulation up-regulates the normal physiologic expression of not just one, but various factors
       - Allows synergistic relationships between growth factors
       - Enhances fusion success without the potential concerns
         associated with single growth factor treatments
  • Cathode placement against and across the decorticated transverse processes resulted in enhanced bone formation throughout the entire fusion mass rather than just along the transverse processes

To learn more about published pre-clinical data, please refer to the SpF® Stimulator Technical Monograph found below.

SpF® Stimulator Technical Monograph.pdf

* Denotes significant difference.
** In vitro cellular and pre-clinical studies may not be indicative of human clinical outcomes.
These charts were created by Biomet based on published data.
  • Morone, M.A. et al. Gene Expression During Autograft Lumbar Spine Fusion and the Effect of Bone Morphogenetic Protein 2. CORR. 1998;351: 252-265


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